Ali Ahmad

Biography

Team

• Ayoub Abulkhir, M.Sc.
• Suzanne Samarani, Ph.D.

Themes

• Immunology
• Virology
• Inflammation

Research topics

• Immunology of HIV infection/AIDS.
• Immunopathogenesis of Crohn disease
• Innate immunity in cancer (leukemia)

Publications (selected)

• Kumar V, Ahmad A. Role of MAIT cells in the immunopathogenesis of inflammatory diseases: New players in old game. Int Rev Immunol. 2018 Mar 4;37(2):90-110.
• Allam O, Samarani S, Jenabian MA, Routy JP, Tremblay C, Amre D, Ahmad A. Differential synthesis and release of IL-18 and IL-18 Binding Protein from human platelets and their implications for HIV infection. Cytokine. 2017 Feb; 90: 144-154.
• Abulkhir A, Samarani S, Amre D, Duval M, Haddad E, Sinnett D, Leclerc JM, Diorio C, Ahmad A. A protective role of IL-37 in cancer: a new hope for cancer patients. J Leukoc Biol. 2017 Feb; 101(2):395-406.
• Ahmad A, Rinaldo CR. A novel anti-HIV immunotherapy to cure HIV. AIDS. 2017 Jan 28; 31(3):447-449.
• Iannello A, Samarani S, Allam O, Jenabian MA, Mehraj V, Amre D, Routy JP, Tremblay C, Ahmad A. A potentially protective role of IL-18 Binding Protein in HIV-infected Long-Term Non-Progressors. Cytokine. 2017 Feb; 90:96-99.
• Ahmad A, Mehraj V, Jenabian MA, Samarani S, Tremblay C, Routy JP. Combination antiretroviral therapy and indoleamine 2,3-dioxygenase in HIV infections: challenges and new opportunities. AIDS. 2016 Jul 17; 30 (11):1839-41.
• Suzanne Samarani, Ossama Allam, Patrick Sagala, Zainab Aldabah, Mohammad-Ali Jenabian, Vikram Mehraj, Cécile Tremblay, Jean-Pierre Routy, Devendra Amre and Ali Ahmad. Imbalanced production of IL-18 and its antagonist in human diseases, and its implications for HIV-1 infection. Cytokine; 2016 Jun; 82:38-51.
• Allam O, Samarani S, Ahmad A. Mesenchymal Stem Cell Therapy in HIV-infected HAART-treated Non-immune Responders restores Immune Competence. AIDS. 2013; May 15; 27(8):1349-52.
• Allam O, Samarani S, Ahmad A. Microbial translocation and AIDS-associated lymphomas: crux of the problem. AIDS. 2013 Jan 28; 27(3):477-8.
• Allam O, Samarani S, Ahmad A. 2011. Hammering out HIV-1 incidence with Hamming Distance. AIDS, 25 (16): 2047-8.
• Zaema Almalte, Suzanne Samarani, Alexandre Iannello, Olfa Debbeche, Devendra K Amre, Daniel Sinnett and Ali Ahmad. 2011. Association of activating Killer-cell Immunoglobulin-like Receptor genes with decreased risk for developing B cell acute lymphoblastic leukemia in children. Blood 118(5):1323-8.
• Alexandre Iannello, Mohamed-Rachid Boulassel, Suzanne Samarani, Cécile Tremblay, Emil Toma, Jean-Pierre Routy and Ali Ahmad. 2010. IL-21 enhances NK cell functions and survival in healthy and HIV-infected patients with minimal stimulation of viral replication. J Leuk Biology 87(5): 857-67.
• Alexandre Iannello, Suzanne Samarani, Mohamed-Rachid Boulassel, Cécile Tremblay, Emil Toma, Jean-Pierre Routy and Ali Ahmad. 2010. HIV causes imbalance in production of interleukin-18 and its natural antagonist in HIV-infected AIDS patients: implications for enhanced viral replication. Journal of Infectious Diseases 201 (4): 608-17.
• Alexandre Iannello, Suzanne Samarani, Olfa Debbeche, Mohamed-Rachid Boulassel, Cécile Tremblay, Emil Toma, Jean-Pierre Routy and Ali Ahmad. 2010. Dynamics and consequences of IL-21 production in HIV-infected persons: A longitudinal and cross sectional study. Journal of Immunology 184 (1): 114-26.
• Alexandre Iannello, Suzanne Samrani, Olfa Debbeche, Rasheed Ahmad, Mohamed-Rashid Boulassel, Cécile Tremblay, Emil toma, Jean-Pierre Routy and Ali Ahmad.2009. Potential role of IL-18 in the immunopathogenesis of AIDS: involvement in fratricidal killing of NK cells and enhanced HIV replication. Journal of Virology 83(12): 5999-6010.
• Alexandre Iannello, Suzanne Samarani, Olfa Debbeche, Mohamed-Rachid Boulassel, Cécile Tremblay, Emil Toma, Jean-Pierre Routy and Ali Ahmad. 2009. Role of Interleukin-18 in the development and pathogenesis of AIDS. AIDS Reviews, 11(3): 115-25.
• Iannello A, Debbeche O, Samarani S, and Ahmad A. 2008. Antiviral NK Cell Responses in HIV Infection: I. NK cell receptor genes as determinants of resistance to HIV infection and progression to AIDS. First part of An Editor-solicited state-of-the-art review article on the subject. Journal of Leukocyte Biology 84(1): 1-26.
• Ahmad R, Iannello A, Samarani S, Toma E, Morisset R, Grosley M, Ahmad A. 2006. Contribution of platelet activation to plasma IL-18 concentrations in HIV-infected AIDS patients. AIDS 20 (14): 1907-9.
• Ahmad A and F. Alvarez. 2004. Role of NK and NKT Cells in the immunopathogenesis of HCV-induced Hepatitis. Journal of Leukocyte Biology. 76: 743-759.
• Ahmad, R., S.T.A.K. Sindhu, E. Toma, R. Morisset, and A. Ahmad. 2002. Elevated levels of circulating IL-18 in HIV-infected individuals: Role of peripheral blood mononuclear cells and implications for AIDS pathogenesis. J. Virology 76(24): 12448-56.
• A. Subbramanian, J.W. Xu, E. Toma, R. Morisset, E. Cohen, J. Menezes, A. Ahmad. 2002. Comparison of human immunodeficiency virus (HIV)-specific infection-enhancing and –inhibiting antibodies in AIDS patients. J. Clin. Microbiology 40:2141-2146.
• Ahmad R, S.T.A.K. Sindhu, P. Tran, E. Toma, R. Morisset, J. Menezes, A. Ahmad. 2001. Modulation of the expression of the MHC class I-binding natural killer (NK cell receptors and NK activity in relation to viral load in HIV-infected/AIDS patients. J. Medical Virology 65:431-440.
• Ahmad R, S.T.A.K. Sindhu, E. Toma, R. Morisset, J. Vincilitte, J. Menezes, A. Ahmad. 2001. Evidence for a correlation between antibody-dependent cellular cytotoxicity-mediating anti-HIV-1 antibodies and prognostic predictors of HIV infection. J. Clinical Immunology 21:227-233
• Ahmad A, E. Sharif-Askari, L. Fawaz, J. Menezes. 2000. Innate immune response of human host to infection with Herpes simplex virus type-1: In vitro control of infection by enhanced natural killer cytolytic activity via IL-15 induction. J. Virology 74:7196-7203.
• Xu JW, J. Menezes, U. Prasad, A. Ahmad. 1999. Elevated serum levels of transforming growth factor-1 in Epstein-Barr virus-associated nasopharyngeal carcinoma patients. Int. J. Cancer 84: 396-399.
• Ahmad A, J. Menezes. 1997. The binding of Epstein-Barr virus to human platelets causes the release of transforming growth factor-ß. J. Immunology. 159: 3984-3988.
• Ahmad A, J. Menezes. 1996. Antibody-dependent cellular cytotoxicity in HIV-infections FASEB Journal 10: 258-266.
• Ahmad A, J. Menezes. 1996. Defective killing activity against gp120/41-expressing human erythroleukaemic K562 cell line by monocytes and natural killer cells from HIV-infected individuals. AIDS 10: 143-149.
• Ahmad A, J. Menezes. 1995. Positive correlation between natural killer and gp120 specific antibody dependent cellular cytotoxic effector functions of the peripheral blood mononuclear cells in HIV-infected individuals. J. Acq. Immune Deficiency Syndrome & Human Retrovirology 10: 115-119.
• Ahmad A, A. Ladha, E.A. Cohen, J. Menezes. 1993. Stable expression of the transfected HIV-1 env gene in a human B cell line: Characterization of gp120-expressing clones and immunobiological studies. Virology 192: 447-457.
• Ahmad A, C.H. Wang, R.G. Bell. 1991. A role for IgE in intestinal immunity: Expression of rapid expulsion of Trichinella spiralis in rats transfused with IgE and thoracic duct lymphocytes. Journal of Immunology 146: 3563-3570.
• Korenaga M, C.H. Wang, R.G. Bell, D. Zhu, A. Ahmad. 1989. Intestinal immunity to Trichinella spiralis is a property of OX8- OX22- T helper cells that are generated in the intestine. Immunology. 66: 588-594.