Guy Lemay

Title: Professor
Address: Département de microbiologie, infectiologie et immunologie
Pavillon Roger-Gaudry
Université de Montréal
C.P. 6128, Succ. Centre-ville
Montréal (Québec)  H3C 3J7
Room: Office: S-627
Lab:U-607
Phone: Office: 514 343-2422
Lab: 514 343-6111, ext. 3146
Fax: 514 343-5701
Email: guy.lemay@umontreal.ca


Biography

Dr. Guy Lemay holds a bachelor’s degree and a master’s degree in microbiology and immunology from the Université de Montréal. His master’s work under the direction of Dr. Paul Jolicoeur at the Montreal Clinical Research Institute focused on the integration of retroviral DNA in rat tumors. Subsequently, Dr. Lemay pursued his doctoral studies under the direction of Dr. Stewart Millward, Department of Biochemistry, McGill University. His work allowed to demonstrate the importance of a reovirus protein in the control of protein synthesis during infection. Dr. Lemay subsequently developed his expertise in enzymology and protein biochemistry during a postdoctoral fellowship under the direction of Dr. Guy Boileau, Department of Biochemistry, Université de Montréal. He was subsequently recruited as a professor in the Department of Microbiology and Immunology in 1989. As the recipient of a scholarship from the Fonds de recherche en santé du Québec from 1991 to 2003, he developed several research aspects mainly on replication of mammalian retroviruses and reoviruses. Recently, most of his research is focused on the replication of the latter to better understand their ability to destroy cancer cells. Dr. Lemay is the author of 73 publications in world-class journals and of 125 scientific communications in his career. In recent years he has also been actively involved in lectures for the general public and has been the recipient of an award from the Association francophone pour le savoir. His excellence in teaching activities has also been recognized by a prize from the Université de Montréal in 2015. Over the years, he has also been actively involved in the operation of the institution as the chair of the graduate and undergraduate programs of the department and department head, among others.


Team

  • Delphine Lanoie, M.Sc.
  • Claude Marchand, Ph.D. (co-supervision)
  • Simon Boudreault, Ph.D. (co-supervision, Université de Sherbrooke)

Theme

  • Virology

Research topics

  • Impact of interferon on reovirus replication
  • Reovirus oncolytic activity: mechanism and optimization of viral strains
  • Reovirus adaptation during viral persistence
  • Enzyme activities of reovirus capsid proteins
  • Reovirus reverse genetics
  • Cellular transcriptome during reovirus infection
  • Synthesis and structure of reovirus messenger RNAs

Publications

  • Jabre, R., Sandekian, V. and Lemay, G. (2013) Amino acid substitutions in sigma1 and mu1 outer capsid proteins are selected during mammalian reovirus adaptation to Vero cells. Virus Res. 176:188-198.
  • Sandekian, V. and Lemay, G. (2015) A single amino acid substitution in the mRNA capping enzyme λ2 of a mammalian orthoreovirus mutant increases interferon sensitivity. Virology 483(C):229-235.
  • Boudreault, S., Martenon-Brodeur, C., Caron, M., Garant, J.-M., Tremblay, M.-P., Armero, V.E.S., Durand, M., Lapointe, E., Thibault, P., Tremblay-Létourneau, M., Perreault, J.-P., Scott, M.S., Lemay, G. and Bisaillon, M. (2016) Global profiling of the cellular alternative RNA splicing landscape during virus-host interactions. PloS ONE 11:e-0161914-21.
  • Lanoie, D. and Lemay, G. (2018) Multiple proteins differing between laboratory stocks of mammalian orthoreoviruses affect both virus sensitivity to interferon and induction of interferon production during infection. Virus Res. In press.