| Title: | Full research professor (accredited) Département de médecine et spécialités médicales |
| Address: | Unité de recherche sur la biologie moléculaire de la cellule B Institut de recherches cliniques de Montréal 110, avenue des Pins Ouest Montréal (Québec) H2W 1R7 |
| Room: | Labo 7725 |
| Phone: | Office: 514-987-5642 Labo: 514-987-5660 |
| Fax: | 514-987-5528 |
| Email: | jm.di.noia@umontreal.ca javier.di.noia@ircm.qc.ca |
| Web site: | www.dinoialab.ca |
Biography
Update coming soon
Team
- Astrid Zahn, PhD (research associate and lab manager)
- P Ganesh Subramani (étudiant de doctorat)
- Noé Seija (étudiant de doctorat)
- Kiersten Dionne (étudiante de doctorat)
- Jana Ridani (étudiante de doctorat)
- Silvana Ferreira (post-doctorante)
- Paul Donnelly (étudiant de maîtrise)
Theme
- Immunology
Research topics
- The molecular mechanisms of antibody diversification by the mutagenic enzyme Activation induced deaminase in germinal center B cells.
- The mechanisms that enforce an equilibrium between the benefits of antibody diversification and its pathogenic side effects.
- The dynamics of mutation and survival of B cells in the germinal center that underlie an effective antibody response.
- The relevance of DNA repair enzymes during antibody gene diversification their exploitation for possible therapeutic applications.
- Characterization of functions catalyzed by novel deaminase enzymes present only in vertebrates.
Publications
Safavi S, Larouche A*, Zahn A*, Patenaude A-M, Domanska D, Dionne K, Rognes T, Dingler F, Kang S-K, Liu Y, Johnson N, Hébert J, Verdun RE, Rada CA, Vega F, Nilsen H, Di Noia JM#. The uracil-DNA glycosylase UNG protects the fitness of normal and cancer B cells expressing AID. NAR Cancer, 2020, 2(3):zcaa019.
Feng Y*, Seija N*, Di Noia JM#, Martin A#. AID in Antibody Diversification: There and Back Again. Trends Immunol. 2020 Apr 27:S1471-4906(20)30089-2.
Litzler LC, Zahn A, Meli AP, Hébert S, Patenaude A-M, Methot SP, Sprumont A, Bois T, Kitamura D, Constantino C, King IL, Kleinman CL, Richard S, and Di Noia JM#. PRMT5 is essential for B cell development and for the antibody response by regulating germinal center dynamics. Nat Commun. 2019; 10(1):22.