| Title: | Full time professor Département de médecine et spécialités médicales |
| Address: | Maisonneuve-Rosemont Hospital Research Center Polyclinique #305 5415 l’Assomption Blvd Montreal (Quebec) H1T 2M4 |
| Phone: | Office: 514 252-3552 Lab : 514-252-3400 #4643 |
| Fax: | 514 253-7626 |
| Email: | nathalie.labrecque@umontreal.ca |
Biography
Education:
| 1994-2000 | Post-doctoral fellow (Christophe Benoist and Diane Mathis), IGBMC, France |
| 1988-1994 | Ph D. (Rafick-Pierre Sékaly), IRCM, Université de Montréal, Canada |
Distinctions and achievements:
| 2021 | Investigator Award, Canadian Society for Immunology |
| 2014-2015 | Ph. D. Professor of the year, faculty of medicine – Université de Montréal |
| 2008-2011 | Senior Investigator Grant, FRQS |
| 2002-2007 | New Investigator Award, CIHR |
| 1997-1999 | Centennial Award, Medical Research Council of Canada |
Team
- Laure Le Corre, Ph. D. student
- Sarh Mezrag, M. Sc. student
- Salix Boulet Ph. D., Research associate
- Jean-François Daudelin M. Sc., Lab manager
- Dave Maurice-De Sousa, Ph. D. student
- Livia Odagiu, Ph. D. student
Theme
Molecular Immunology
Research topics
The main goal of our research group is to determine the factors involved in the differentiation of effector and memory CD8+ T cells. More specifically, we are interested in the Notch signaling pathway and the orphan receptor NR4A3 in acute (Listeria monocytogenes and LCMV Armstrong) and chronic (LCMV clone 13) infectious mouse models. In addition, we are currently exploring the advantages of using resident memory T cells in adoptive cell transfer to treat cancer. In parallel, we are deciphering the role of NR4A3 in different dendritic cell sub-populations. In order to attain our objectives, we use cutting edge technology, such as flow cytometry, RNA-sequencing, In vivo Imaging System (IVIS), quantitative PCR and chromatin immunoprecipitation (ChIP).
Publications
Boulet S, Odagiu L, Dong M, Lebel MÈ, Daudelin JF, Melichar HJ, Labrecque N. NR4A3 Mediates Thymic Negative Selection. J Immunol. 2021 Jul 26:ji1901228. doi: 10.4049/jimmunol.1901228. Online ahead of print.PMID: 34312259
Odagiu L, Boulet S, Maurice De Sousa D, Daudelin JF, Nicolas S, Labrecque N. Early programming of CD8+ T cell response by the orphan nuclear receptor NR4A3. Proc Natl Acad Sci U S A. 2020 Sep 29;117(39):24392-24402.
Nobis CC, Dubeau Laramée G, Kervezee L, Maurice De Sousa D, Labrecque N*, Cermakian N*. The circadian clock of CD8 T cells modulates their early response to vaccination and the rhythmicity of related signaling pathways. Proc Natl Acad Sci U S A. 2019 Oct 1;116(40):20077-20086.
Boulet S, Daudelin JF, Odagiu L, Pelletier AN, Yun TJ, Lesage S, Cheong C, Labrecque N. The orphan nuclear receptor NR4A3 controls the differentiation of monocyte-derived dendritic cells following microbial stimulation. Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):15150-15159.
Mathieu M, Duval F, Daudelin JF, Labrecque N. The Notch signaling pathway controls short-lived effector CD8+ T cell differentiation but is dispensable for memory generation. J Immunol. 2015 Jun 15;194(12):5654-62.
Complete list of Dr Labrecque’s publications:
https://www.ncbi.nlm.nih.gov/pubmed/?term=nathalie+labrecque