Nicolas Chomont

Chomont Nicolas f

Title: Associate research professor
Address: Centre de Recherche du CHUM
Axe Immunopathologie900 rue Saint-Denis
Tour Viger, Pavillon R
Montreal, QC H2X 0A9
Room: Office: R09.430
Labo: R09.300
Phone: Office: 514-890-8000, ext. 31266
Labo: 514-890-8000, ext. 31247
Fax: 514-412-7936
Email: nicolas.chomont@umontreal.ca

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Biography

Dr. Nicolas Chomont is an Associate research professor in the Department of Microbiology, Infectiology and Immunology at the Université de Montréal. His laboratory is located at the Research Center of the CHUM (CRCHUM). Dr. Chomont received his doctorate in medical virology at the Pierre and Marie Curie University (Paris VI) under the direction of Prof. Laurent Bélec in the laboratory of Prof. Michel Kazatchkine. He studied the interactions between HIV and genital mucosa and their implications for the sexual transmission of the virus. Between 2004 and 2009, he completed a postdoctoral internship in Dr. Rafick Sékaly’s laboratory at the Université de Montréal and the CRCHUM. His work has led to the identification of the cellular reservoirs of HIV that are responsible for the persistence of the virus during antiretroviral therapies. Dr. Chomont then moved to VGTI-Florida where he was named “Associate Member”. As an independent researcher, he has continued to characterize viral reservoirs as the major obstacle to the eradication of HIV. Since January 2015, Dr. Chomont has joined the Université de Montréal and the CRCHUM where he leads a research program aimed at dissecting the molecular and immunological mechanisms involved in viral latency and developing new therapeutic strategies aimed at Elimination of HIV reservoirs.


Team

  • Rémi Fromentin, PharmD, PhD, Associé de recherche
  • Amélie Pagliuzza, M.Sc., Assistante de recherche
  • Hawley Rigsby, B.Sc, Assistante de recherche
  • Marion Pardons, étudiante au doctorat
  • Caroline Dufour, étudiante au doctorat
  • Johann Plantin, étudiant à la maîtrise
  • Louise Leyre, étudiante à la maîtrise
  • Marta Massanella-Luna, PhD, Stagiaire postdoctoral
  • Julia Ruiz, PhD, Stagiaire postdoctoral


Themes

  • Immunology
  • Virology


Research topics

  • Characterization of cellular and anatomical reservoirs of HIV during triple therapy
  • Study of the molecular mechanisms of HIV latency
  • Development of new tools to characterize and quantify HIV reservoirs
  • Development of therapeutic strategies to eliminate reservoirs of HIV


Publications

  • Fromentin, R., W. Bakeman, M. B. Lawani, G. Khoury, W. Hartogensis, S. DaFonseca, M. Killian, L. Epling, R. Hoh, E. Sinclair, F. M. Hecht, P. Bacchetti, S. G. Deeks, S. R. Lewin, R. P. Sekaly, and N. Chomont. 2016. CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART. PLoS Pathog 12: e1005761.
  • Vandergeeten, C., R. Fromentin, E. Merlini, M. Bramah-Lawani, S. DaFonseca, S. Bakeman, A. McNulty, M. Ramgopal, N. Michael, J. H. Kim, J. Ananworanich, and N. Chomont. 2014. Cross-clade Ultrasensitive PCR-based Assays to Measure HIV Persistence in Large Cohort Studies. J Virol 88: 12385-12396.
  • Vandergeeten, C., R. Fromentin, S. DaFonseca, M. B. Lawani, I. Sereti, M. M. Lederman, M. Ramgopal, J. P. Routy, R. P. Sekaly, and N. Chomont. 2013. Interleukin-7 promotes HIV persistence during antiretroviral therapy. Blood 121: 4321-4329.
  • Chomont, N., M. El-Far, P. Ancuta, L. Trautmann, F. A. Procopio, B. Yassine-Diab, G. Boucher, M. R. Boulassel, G. Ghattas, J. M. Brenchley, T. W. Schacker, B. J. Hill, D. C. Douek, J. P. Routy, E. K. Haddad, and R. P. Sekaly. 2009. HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation. Nat Med 15: 893-900.