J. Daniel Dubreuil

Dubreuil J. Daniel

Title: Full time professor (accredited)
Address: Département de pathologie et microbiologie
Faculté de médecine vétérinaire
Université de Montréal
1500, av. Des vétérinaires
Saint-Hyacinthe (Québec)
J2S 8H5
Room: Office: 3442
Labo: 3127
Phone: Office: 450-773-8521 ext. 8433
Labo: 450-773-8521 ext. 8367
Fax: 450-778-8108
Email: daniel.dubreuil@umontreal.ca
Web site: My personal web page


Dr. Dubreuil received a B.Sc. (Agr.) From Macdonald College (McGill University), a Master’s degree from the Université de Montréal and a Ph.D. (Department of Microbiology and Immunology, Université de Montréal) ‘Institut Armand-Frappier. A first year of postdoctoral study was conducted at the Pasteur Institute of Paris (Antibacterial Agents Unit) and two others in the Department of Biochemistry and Microbiology (Victoria University, British Columbia, Canada). He joined the faculty of the Faculty of Veterinary Medicine at the Université de Montréal in 1988. In June 2001, he was a one-year study and research intern at the Instituto di Ricerche Immunobiologiche Siena-Chiron, A pharmaceutical research center located in Siena, Italy. In this center, he carried out research on the virulence of Helicobacter pylori. He is the author of more than 120 scientific publications, including numerous journals and several book chapters on Escherichia coli toxins. Very involved with the Canadian Society of Microbiologists, he was elected President for the period 2013-2014. Since June 2014, he has been Director of the Department of Pathology and Microbiology of the Faculty of Veterinary Medicine.




  • Bacteriology

Research topics

  • Study of STb enterotoxin produced by Escherichia coli. Internalization pathways of STb. Mechanism of action of the toxin.
  • Study of EAST1 toxin produced by E. coli. Study of EAST1 variants in relation to toxicity. Identification, cloning, expression, purification and comparison of the toxicity using the suckling mouse assay and the Ussing chamber.



  • Dubreuil, J.D. (2018). Escherichia coli STb enterotoxin: A multifaceted molecule. Toxinology. Microbial toxins. Edited by P. Gopalakrishnakone, A. Alape-Giron, J.D. Dubreuil, M. Mandal and B. Stiles. Springer.
  • Dubreuil J.D.(2017) Enterotoxigenic Escherichia coli targeting intestinal epithelial tight junctions: An effective way to alter the barrier integrity. Microbial Pathogenesis 113:129-134.
  • Dubreuil J.D. (2017) Enterotoxigenic Escherichia coli and probiotics in swine: what the bleep do we know? Bioscience Microbiota Food Health. 36:75-90.
  • Dubreuil J.D., Isaacson R.E., Schifferli D.M. (2016) Animal Enterotoxigenic Escherichia coli. EcoSal Plus. 2016 Oct;7(1). Doi : 1128/ecosalplus.ESP-0006-20.
  • Dubreuil, J.D. (2015). Escherichia coli heat-stable enterotoxins. (Chapter 31). In: The Comprehensive Sourcebook of Bacterial Protein Toxins, 4th edition. Edited by Joseph Alouf, Daniel Ladant and Michel R. Popoff. Elsevier. p.874-910.
  • Nassour H. et Dubreuil J.D. (2014) Escherichia coli STb enterotoxin dislodges claudin-1 from epithelial tight junctions.  PLoS One :e113273. Doi :10.1371/journal.pone.0113273.
  • Dubreuil, J.D. (2014). Escherichia coli/Enterotoxigenic E. coli (MS385). Carl Batt and Mary-Lou Tortorello (eds.). Encyclopedia of food microbiology- 2nd edition. Elsevier p. 728-734.
  • Ngendahayo Mukiza C. et Dubreuil J.D. (2013) Escherichia coli heat-stable toxin b impairs intestinal epithelial barrier function by altering tight junction proteins. Infection and Immunity 81:2819-2827.
  • Dubreuil J.D. (2013) Antibacterial and antidiarrheal activities of plant products against enterotoxinogenic Escherichia coli. Toxins (Basel). 5:2009-2041.