| Title: | Full time professor (accredited) Département de médecine et spécialités médicales |
| Address: | Laboratoire de recherche en autoimmunité (LABRAI) Centre de recherche du CHUM Tour Viger R11.428 900, rue Saint-Denis Montréal (Québec) H2X 0A9 |
| Phone: | 514 890-8000, poste 25364 |
| Email: | LABRAI-JL.SENECAL@outlook.com |
Biography
To come up
Team
To come up
Theme
To come up
Research topics
- Human systemic autoimune diseases :
- Identification, characterization and clinical significance of autoantibodies associated with human systemic autoimmune diseases: scleroderma (systemic sclerosis), systemic lupus erythematosus (SLE) and autoimmune myositis.
- Molecular mechanisms in the immunopathogenesis of scleroderma and SLE.
- Role of apoptosis in the generation of autoantigens and their role in the immunopathogenesis of scleroderma and SLE.
- Development of new therapies for scleroderma and SLE.
Publications
- Mehta H, Goulet PO, Mashiko S, Desjardins J, Pérez G, Koenig K, Senécal JL, Constante M, Santos MM, Sarfati M. Exposure to antibiotic limited to early life causes intestinal dysbiosis and exacerbates skin and lung pathology in murine experimental systemic sclerosis. J Inv Derm (2017) 137:2316-2325.doi:10.1016/j.jid.2017.06.019.
- Senécal JL, Raynauld JP, Troyanov Y. A new classification of autoimmune myositis. Editorial. Arthritis Rheumatol (2017) 69(5):878-884. doi: 10.1002/art.40063.
- Hoa S, Troyanov Y, Fritzler MJ, Targoff IN, Chartrand S, Mansour AM, Rich E, Boudabbouz H, Bourré-Tessier J, Goulet JR, Albert M, Landry M, Senécal JL. Anti-MDA5-associated rapidly progressive interstitial lung disease: defining suggestive clinical, biochemical and radiological features and expanding the clinical spectrum. Case series of 10 Canadian patients and literature review. Scand J Rheumatol (2017) 25:1-15. doi: 10.1080/03009742.2017.1334814.