| Title: | Full time professor (accredited) Département de médecine et spécialités médicales |
| Address: | Centre de recherche du CHUM 900, rue Saint-Denis, Pavillon R Montréal (Québec) H2X 0A9 |
| Phone: | 514 890-8000, ext. 25394 |
| Email: | m.sarfati@umontreal.ca |
Biography
MD PhD
Directeor of Immunoregulation laboratory (CRCHUM).
Full Professor, Department of Medicine, University of Montreal
Team
- Marwa Bsat, Ph.D student.
- Laurence Anne Chapuy, Ph.D student.
- Heena Mehta, Research Associate
- AmélieTherrien, MSc student.
- Shunya Mashiko, Research Assistant
- Manuel Rubio, Research Assistant
Themes
Skin chronic inflammatory diseases ( psoriasis, atopic dermatitis, systemic sclerosis)
Inflammatory bowel diseases (Crohn’s disease and ulcerative colitis)
Allergic diseases
Research topics
- Chracterization and fonction of innate immune cells and T lymphocytes in tissue of patients with chronic inflammatory diseases
Publications
Early-Life Antibiotic Exposure Causes Intestinal Dysbiosis and Exacerbates Skin and Lung Pathology in Experimental Systemic Sclerosis.Mehta H, Goulet PO, Mashiko S, Desjardins J, Pérez G, Koenig M, Senécal JL, Constante M, Santos MM, Sarfati M.J Invest Dermatol. 2017 Nov;137(11):2316-2325. doi: 10.1016/j.jid.2017.06.019. Epub 2017 Jul 27.
Increased frequencies of basophils, type 2 innate lymphoid cells and Th2 cells in skin of patients with atopic dermatitis but not psoriasis.Mashiko S, Mehta H, Bissonnette R, Sarfati M.J Dermatol Sci. 2017 Nov;88(2):167-174. doi: 10.1016/j.jdermsci.2017.07.003. Epub 2017 Jul 15.
Persistence of interleukin (IL)-17A+ T lymphocytes and IL-17A expression in treatment-resistant psoriatic plaques despite ustekinumab therapy.Jack C, Mashiko S, Arbour N, Bissonnette R, Sarfati M.Br J Dermatol. 2017 Jul;177(1):267-270. doi: 10.1111/bjd.15029. Epub 2017 Jun 6.
Differential accumulation and function of proinflammatory 6-sulfo LacNAc dendritic cells in lymph node and colon of Crohn’s versus ulcerative colitis patients.Bsat M, Chapuy L, Baba N, Rubio M, Panzini B, Wassef R, Richard C, Soucy G, Mehta H, Sarfati M.J Leukoc Biol. 2015 Oct;98(4):671-81. doi: 10.1189/jlb.5A1014-509RR. Epub 2015 Jul 10.
Mutual Interaction of Basophils and T Cells in Chronic Inflammatory Diseases.Sarfati M, Wakahara K, Chapuy L, Delespesse G. Front Immunol. 2015 Aug 3;6:399. doi: 10.3389/fimmu.2015.00399. eCollection 2015. Review.
Basophils increase in Crohn disease and ulcerative colitis and favor mesenteric lymph node memory TH17/TH1 response.Chapuy L, Bsat M, Mehta H, Rubio M, Wakahara K, Van VQ, Baba N, Cheong C, Yun TJ, Panzini B, Wassef R, Richard C, Tamaz R, Soucy G, Delespesse G, Sarfati M.J Allergy Clin Immunol. 2014 Oct;134(4):978-81.e1. doi: 10.1016/j.jaci.2014.05.025. Epub 2014 Jul 2.
CD47 fusion protein targets CD172a+ cells in Crohn’s disease and dampens the production of IL-1β and TNF.Baba N, Van VQ, Wakahara K, Rubio M, Fortin G, Panzini B, Soucy G, Wassef R, Richard C, Tamaz R, Lahaie R, Bernard EJ, Caussignac Y, Leduc R, Lougnarath R, Bergeron C, Racicot MA, Bergeron F, Panzini MA, Demetter P, Franchimont D, Schäkel K, Weckbecker G, Kolbinger F, Heusser C, Huber T, Welzenbach K, Sarfati M. J Exp Med. 2013 Jun 3;210(6):1251-63. doi: 10.1084/jem.20122037. Epub 2013 May 13.