Vibhuti Dave

Biography

Dr. Dave received master and doctoral (biochemistry) degrees from University of Mumbai. He then pursued postdoctoral training in immunology at St. Jude Children`s Research Hospital (Memphis, USA) and Fox Chase Cancer Center (Philadelphia, USA). Dr. Dave established his research lab at IRCM. In 2002, he was awarded Canada Research Chair. Presently, he is at Centre de Researche Hopital Maisonneuve-Rosemont (CRHMR) where he is continuing to study CD4/CD8 lineage commitment in thymus and mature T cell function using transgenic and gene deficient mouse models.

Team

• Nabil Zeidan, Ph.D. student.
• Hassan Damen, Ph.D. student.

Theme

• Immunology

Research topics

• Mechanism of ThPOK-mediated CD4/CD8 lineage choice in thymus.
• Understanding T cell exhaustion.
• Chimeric antigen receptor and cancer immunotherapy.

Publications

• Brodeur JF, Li S, Damlaj O, and Dave VP (2009). Expression of of fully-assembled T cell receptor/CD3 complex on double positive thymocytes: synergistic role for the PRS and the ER retention motifs in the intra-cytoplasmic tail of CD3e. International Immunology; 21:1317-1327.
• Brodeur JF, Li S, da Silva Martins M, Larose L, Dave VP (2009). Critical and multiple roles for the CD3epsilon intracytoplasmic tail in double negative to double positive thymocyte differentiation. J Immunol. 182(9);4844-4853.
• Pan Q, Brodeur JF, Drbal K and Dave VP (2006). Different role for mouse and human CD3δ/ε heterodimer in pretT cell receptor (preTCR) function: human CD3d/ε heterodimer restores the defective preTCR function in CD3gδ-deficient mice. Mol Immunol, 43:1741-1750.
• He X, He X, Dave VP, Zhang Y, Hua X, Nicolas E, Xu W, Roe BA, Kappes DJ (2005). The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment. Nature 433(7028):826-833.