{"id":7554,"date":"2014-08-04T13:59:21","date_gmt":"2014-08-04T13:59:21","guid":{"rendered":"https:\/\/microbiologie.umontreal.ca\/sylvie-lesage\/"},"modified":"2021-07-28T14:59:21","modified_gmt":"2021-07-28T13:59:21","slug":"sylvie-lesage","status":"publish","type":"page","link":"https:\/\/microbiologie.umontreal.ca\/en\/professeurs-chercheurs\/sylvie-lesage\/","title":{"rendered":"Sylvie Lesage"},"content":{"rendered":"
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<\/p>\n

\"Lesage.Sylvie\"<\/p>\n

<\/div>\n\n\n\n\n\n\n\n\n
Title:<\/strong><\/td>\nFull professor<\/td>\n<\/tr>\n
Address:<\/strong><\/td>\nH\u00f4pital Maisonneuve-Rosemont
\nCentre de recherche
\n5415, boul. l\u2019Assomption
\nMontr\u00e9al (Qu\u00e9bec) H1T 2M4<\/td>\n<\/tr>\n
Room:<\/strong><\/td>\nRoom 305, polyclinique<\/td>\n<\/tr>\n
Phone:<\/strong><\/td>\nOffice: 514-252-3400,\u00a0ext. 4649
\nLab: 514-252-3400, ext. 4653<\/td>\n<\/tr>\n
Fax:<\/strong><\/td>\n514-252-3430<\/td>\n<\/tr>\n
Email:<\/strong><\/td>\nsylvie.lesage@umontreal.ca<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n\n

Biography<\/strong><\/h2>\n

Dr. Sylvie Lesage received her BSc from the Interdepartmental Immunology Program at McGill University. Subsequently, she completed her Ph.D. in Experimental Medicine under the supervision of Dr. Patrice Hugo, where she studied the mechanisms of central T cell tolerance. She then undertook a postdoctoral internship under the supervision of Dr. Christopher C. Goodnow, recognized internationally for is work in immunogenetics. During this internship in Australia, Dr. Lesage took advantage of murine models to study the genetic predisposition to autoimmune diseases, such as type 1 diabetes. While it was established that peripheral tolerance of lymphocytes T contributed significantly to the predisposition to autoimmune diseases, Dr. Lesage’s work revealed an important contribution of central tolerance. Dr. Lesage opened her laboratory in the fall of 2005 at Maisonneuve-Rosemont Hospital where she established a research team to define the biology and genetics of the immune system’s cellular populations that contribute to immune tolerance and thus preventing autoimmune diseases.<\/p>\n

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Team<\/strong><\/h2>\n