{"id":7585,"date":"2014-07-28T19:45:58","date_gmt":"2014-07-28T19:45:58","guid":{"rendered":"https:\/\/microbiologie.umontreal.ca\/eric-cohen\/"},"modified":"2021-08-16T20:56:26","modified_gmt":"2021-08-16T19:56:26","slug":"eric-cohen","status":"publish","type":"page","link":"https:\/\/microbiologie.umontreal.ca\/en\/professeurs-chercheurs\/eric-cohen\/","title":{"rendered":"\u00c9ric A. Cohen"},"content":{"rendered":"<div  class=\" fiche-chercheur  \">\n<div class=\"img noLightbox\"><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/microbiologie.umontreal.ca\/wp-content\/uploads\/sites\/12\/2021\/08\/EricACohen-352x450.jpg\" alt=\"\" width=\"352\" height=\"450\" class=\"alignnone size-medium wp-image-12193\" srcset=\"https:\/\/microbiologie.umontreal.ca\/wp-content\/uploads\/sites\/12\/2021\/08\/EricACohen-352x450.jpg 352w, https:\/\/microbiologie.umontreal.ca\/wp-content\/uploads\/sites\/12\/2021\/08\/EricACohen.jpg 360w\" sizes=\"auto, (max-width: 352px) 100vw, 352px\" \/><br \/>\n<\/div>\n<table style=\"width: 449px\">\n<tbody>\n<tr>\n<td style=\"width: 93px\"><strong>Title:<\/strong><\/td>\n<td style=\"width: 348px\">Full time professor<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 93px\"><strong>Address:<\/strong><\/td>\n<td style=\"width: 348px\">Human Retrovirology research unit<br \/>\nInstitut de recherches cliniques de Montr\u00e9al (IRCM)<br \/>\n110, avenue des Pins Ouest<br \/>\nMontr\u00e9al (Qu\u00e9bec)<br \/>\nH2W 1R7<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 93px\"><strong>Room:<\/strong><\/td>\n<td style=\"width: 348px\">Laboratory 2340 &#8211; IRCM<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 93px\"><strong>Phone:<\/strong><\/td>\n<td style=\"width: 348px\">Office: 514-987-5804<br \/>\nLabo: 514-987-5690<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 93px\"><strong>Fax:<\/strong><\/td>\n<td style=\"width: 348px\">Office: 514-987-5691<\/p>\n<p>Labo: 514-987-5695<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 93px\"><strong>Email:<\/strong><\/td>\n<td style=\"width: 348px\"><a href=\"mailto:eric.cohen@ircm.qc.ca\">eric.cohen@ircm.qc.ca<\/a><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 93px\"><strong>Web site:<\/strong><\/td>\n<td style=\"width: 348px\"><a href=\"https:\/\/ircm.qc.ca\/en\/research\/immunity-and-viral-infections\/human-retrovirology\">My personal page<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><a href=\"http:\/\/www.cancurehiv.org\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-4135 alignleft\" alt=\"CanCURE logo_FR_COLOR\" src=\"https:\/\/microbiologie.umontreal.ca\/wp-content\/uploads\/sites\/12\/CanCURE-logo_FR_COLOR-300x111.jpg\" width=\"205\" height=\"76\" srcset=\"https:\/\/microbiologie.umontreal.ca\/wp-content\/uploads\/sites\/12\/CanCURE-logo_FR_COLOR-300x111.jpg 300w, https:\/\/microbiologie.umontreal.ca\/wp-content\/uploads\/sites\/12\/CanCURE-logo_FR_COLOR-1024x378.jpg 1024w, https:\/\/microbiologie.umontreal.ca\/wp-content\/uploads\/sites\/12\/CanCURE-logo_FR_COLOR-200x74.jpg 200w, https:\/\/microbiologie.umontreal.ca\/wp-content\/uploads\/sites\/12\/CanCURE-logo_FR_COLOR-295x109.jpg 295w, https:\/\/microbiologie.umontreal.ca\/wp-content\/uploads\/sites\/12\/CanCURE-logo_FR_COLOR-198x73.jpg 198w, https:\/\/microbiologie.umontreal.ca\/wp-content\/uploads\/sites\/12\/CanCURE-logo_FR_COLOR-604x223.jpg 604w, https:\/\/microbiologie.umontreal.ca\/wp-content\/uploads\/sites\/12\/CanCURE-logo_FR_COLOR.jpg 1731w\" sizes=\"auto, (max-width: 205px) 100vw, 205px\" \/><\/a><\/div>\n<p>Canadian HIV Cure Enterprise (CanCURE)<\/p>\n<hr\/>\n<h2 style=\"text-align: justify\"><strong>Biography<\/strong><\/h2>\n<p style=\"text-align: justify\">Dr. \u00c9ric A. Cohen is the Director of the Human Retrovirology unit at the Institut de recherches cliniques de Montr\u00e9al (IRCM). He is also a professor of Virology in the Department of Microbiology, Infectiology and Immunology at the Faculty of Medicine of the Universit\u00e9 de Montr\u00e9al. Dr. Cohen holds also the Universit\u00e9 de Montreal- IRCM Chair of Excellence in HIV Research.<\/p>\n<p style=\"text-align: justify\">Dr. Cohen holds a B.Sc. in Biochemistry from McGill University and a Ph.D. in Molecular Biology from the Universit\u00e9 de Montr\u00e9al (Ph.D. under the supervision of Dr. Yves Langelier). During his postdoctoral training (under the supervision of Dr. William Haseltine) at the Dana Farber Cancer Institute at Harvard University, he contributed significantly to the global efforts to characterize the genetic organization and structure of the Human Immunodeficiency Virus (HIV). His initial work led to the discovery of two proteins, Vpr and Vpu, which belong to a class of HIV proteins, named accessory proteins, whose role is to promote viral persistence in spite of the host adaptive and innate\/intrinsic immune responses. Dr. Cohen\u2019s current research directions aim to better understand HIV-host interactions regulating viral replication, transmission, and persistence using state-of-the-art experimental approaches.<\/p>\n<p style=\"text-align: justify\">Since 2014, Dr. Cohen leads the Canadian HIV Cure Enterprise (CanCURE: <a href=\"http:\/\/www.cancurehiv.org\/\">www.cancurehiv.org<\/a>), a pan-Canadian collaboration dedicated to the study of long-lived HIV reservoirs and the development of effective therapeutic strategies towards an HIV Cure. This scientific program is supported by the Canadian Initiative for HIV Cure Research, created through a partnership between the Canadian Institutes of Health Research (CIHR), the Canadian Foundation for AIDS Research (CANFAR), and the International AIDS Society (IAS).<\/p>\n<p style=\"text-align: justify\">Dr. Cohen is a member of numerous scientific committees, funding organizations, and international scientific journals. He is also author of over 150 manuscripts and books published in high-impact scientific and medical journals, as well as the holder of several international patents. Dr. Cohen is strongly involved in the Canadian and Quebec scientific community in the field of HIV\/AIDS. He is a member of the Scientific Committee of the AIDS and Infectious Disease Network of the <em>Fonds de recherche du Qu\u00e9bec-Sant\u00e9<\/em> (FRQ-S) and a member of the steering committee of the Canadian Institutes of Health Research (CIHR) Canadian HIV clinical Trial Network (CTN). He was also a member of the CIHR HIV\/AIDS Research Advisory Committee (CHARAC) from 2010 to 2016. Dr. Cohen was awarded a senior Canada Research Chair (2001-2015) and the Marcel-Pich\u00e9 Prize (2012) in recognition of the excellence of his research. He was also awarded the Pierre-Bois Prize (2014) for his valuable contributions to the development and promotion of the Institut de recherches cliniques de Montr\u00e9al. He was elected a Fellow of the Royal Society of Canada and the Canadian Academy of Health Sciences in 2016.<\/p>\n<p style=\"text-align: justify\"><hr\/><\/p>\n<h2 style=\"text-align: justify\"><strong>Team<\/strong><\/h2>\n<ul style=\"text-align: justify\">\n<li>Tram Pham, Chercheure Senior<\/li>\n<li>Robert Lodge, Chercheur associ\u00e9<\/li>\n<li>Isa Munoz-Arias, Chercheuse associ\u00e9e<\/li>\n<li>Fr\u00e9d\u00e9ric Dallaire, Assistant de recherche<\/li>\n<li>Sharmin Begum, Stagiaire postdoctorale<\/li>\n<li>Nicolas Bellini, \u00c9tudiant au doctorat<\/li>\n<li>Chenrongrong Cai, \u00c9tudiante au doctorat<\/li>\n<li>Jaspreet Jain, Stagiaire postdoctorale<\/li>\n<li>Maria Medina Romero, Stagiaire postdoctorale<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><hr\/><\/p>\n<h2 style=\"text-align: justify\"><strong>Themes<\/strong><\/h2>\n<ul style=\"text-align: justify\">\n<li>Immunology<\/li>\n<li>Virology<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><hr\/><\/p>\n<h2 style=\"text-align: justify\"><strong>Research topics<\/strong><\/h2>\n<ul style=\"text-align: justify\">\n<li>HIV interactions with host cell restriction factors and role of accessory proteins in evading host immunity<\/li>\n<li>HIV-host interactions governing HIV replication, transmission and persistence in lymphoid and myeloid cells<\/li>\n<li>Role of host micro-RNAs in regulating HIV replication, transmission and persistence<\/li>\n<li>Study of HIV replication, transmission and persistence in humanized mouse models<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><hr\/><\/p>\n<h2 style=\"text-align: justify\"><strong>Publications<\/strong><\/h2>\n<p><u>Cong L<\/u>,\u00a0<u>Sugden SM<\/u>, Leclair P., Lim CJ,\u00a0<u>Pham TNQ<\/u>,\u00a0<strong>Cohen EA.<\/strong>\u00a0HIV-1 Vpu promotes phagocytosis of infected CD4<sup>+<\/sup>\u00a0T cells by macrophages through downregulation of CD47.\u00a0<strong><em>mBio<\/em>\u00a0<\/strong>(In Press)<\/p>\n<p><u>Ferreira Barbosa, JA<\/u>\u00a0(*),\u00a0<u>Sparapani, S<\/u>, Boulais<sup>\u00a0<\/sup>J,\u00a0<u>Lodge, R<\/u>, and\u00a0<strong>Cohen EA.\u00a0<\/strong>Human Immunodeficiency Virus Type 1 Vpr mediates degradation of APC1, a scaffolding component of the Anaphase-Promoting Complex\/Cyclosome<strong><\/strong>.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34011540\/\"><em><strong>J. Virol<\/strong>.<\/em>\u00a095; e00971-20 publi\u00e9 en ligne 19 mai, 2021. PMID:\u00a034011540.<\/a><\/p>\n<p><u>Lodge R<\/u>,\u00a0<u>Bellini N<\/u>,\u00a0<u>Laporte M<\/u>, Salahuddin, S, Routy, J-P, Ancuta, P, Costiniuk, CT, Power C, Jenabian M-A,\u00a0\u00a0<strong>Cohen EA.<\/strong>\u00a0Interleukin 1 beta triggers p53-mediated down-modulation of CCR5 and HIV entry in macrophages through microRNAs 103 and 107.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32994328\/\"><em><strong>mBio<\/strong>,<\/em>\u00a029 septembre 2020, 11:e02314-20.\u00a0 PMID: 32994328<\/a><\/p>\n<p><u>Pham TNQ*#<\/u>,\u00a0<u>Meziane O*<\/u>, Miah AM,\u00a0\u00a0<u>Volodina O<\/u>, Colas C, B\u00e9land K, Li Y, Dallaire F, Keler T, Guimond J-V, Lesage S, Cheong C, Haddad \u00c9 , and\u00a0<strong>Cohen EA#.\u00a0<\/strong>Flt3L-Mediated Expansion of Plasmacytoid Dendritic Cells Controls HIV Infection in Humanized Mice.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34011540\/\"><strong><em>Cell Reports<\/em><\/strong>.\u00a0<u>29 (9):\u00a0<\/u>2770-2782, publi\u00e9 en ligne 26 novembre 2019 PMID: 31775044 *<\/a>\u00a0Contributions \u00e9gales; # Auteurs co-correspondants<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Canadian HIV Cure Enterprise (CanCURE) Biography Dr. \u00c9ric A. Cohen is the Director of the Human Retrovirology unit at the Institut de recherches cliniques de Montr\u00e9al (IRCM). He is also [&hellip;]<\/p>\n","protected":false},"author":25,"featured_media":0,"parent":11407,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-7585","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c9ric A. 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