{"id":7693,"date":"2014-09-09T15:21:45","date_gmt":"2014-09-09T15:21:45","guid":{"rendered":"https:\/\/microbiologie.umontreal.ca\/nathalie-grandvaux\/"},"modified":"2018-07-16T16:36:30","modified_gmt":"2018-07-16T15:36:30","slug":"nathalie-grandvaux","status":"publish","type":"page","link":"https:\/\/microbiologie.umontreal.ca\/en\/professeurs-chercheurs\/nathalie-grandvaux\/","title":{"rendered":"Nathalie Grandvaux"},"content":{"rendered":"
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Title:<\/strong><\/td>\nFull professor (accredited)<\/td>\n<\/tr>\n
Address:<\/strong><\/td>\nD\u00e9partement de biochimie et m\u00e9decine mol\u00e9culaire
\nCentre de recherche du CHUM (CRCHUM)
\n900, rue Saint-Denis, Tour Viger, 10e<\/sup> \u00c9tage
\nMontreal, H2X 0A9<\/td>\n<\/tr>\n
Room:<\/strong><\/td>\nR10.470<\/td>\n<\/tr>\n
Phone:<\/strong><\/td>\n514-890-8000, ext. 35292<\/td>\n<\/tr>\n
Email:<\/strong><\/td>\nnathalie.grandvaux@umontreal.ca<\/a><\/td>\n<\/tr>\n
Web site:<\/strong>\u00a0
\n<\/strong><\/td>\n		nathaliegrandvauxlab.com<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n\n

Biography<\/strong><\/h2>\n

After obtaining an engineering degree and a master degree in Biochemistry from the Institut Nationale Des Sciences Appliqu\u00e9es (INSA) in Lyon, Nathalie Grandvaux finished her doctoral studies in 1999 at the University of Grenoble, where she worked on the role of an enzymatic complex involved in the elimination of bacteria that attack the body. This work gives her the opportunity to approach, from a fundamental point of view, the molecular and structural biology of the mechanisms of the innate immune response. During her postdoctoral studies, (2000-2004), Dr. Grandvaux continued her research on the body’s innate response, this time in the context of virus infections. These studies, still fundamental in nature, nevertheless have clinical applications since they contributed to the advancement of knowledge, and ultimately to the identification of new therapeutic targets for viral infections. Recruited by the Universit\u00e9 de Montr\u00e9al, at the Department of Biochemistry and at CRCHUM, Dr. Grandvaux continues to study the host’s defense mechanisms against viral infections, including respiratory viruses. The innate immune response, which constitutes the first line of defense of the organism, also orchestrates the adaptive response which is put in place in a second time. It is therefore essential to unravel the secrets of this primary response to better understand what are the strategies developed by viruses to circumvent the antiviral response and be able to act as early as possible. An original aspect of Dr. Grandvaux’s research is the study of oxidative metabolism in this response. Dr. Grandvaux’s research has, over the last ten years, shown that, at the level of respiratory mucosa, oxygen derivatives (often considered harmful to the body) are necessary to establish an appropriate defense. The ongoing work of Dr. Grandvaux’s group is to determine how these mechanisms can be used in therapeutic strategies.<\/p>\n

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Team<\/strong><\/h2>\n