{"id":7825,"date":"2014-07-31T19:05:19","date_gmt":"2014-07-31T19:05:19","guid":{"rendered":"https:\/\/microbiologie.umontreal.ca\/nathalie-labrecque-ph-d\/"},"modified":"2021-08-03T17:00:18","modified_gmt":"2021-08-03T16:00:18","slug":"nathalie-labrecque-ph-d","status":"publish","type":"page","link":"https:\/\/microbiologie.umontreal.ca\/en\/professeurs-chercheurs\/nathalie-labrecque-ph-d\/","title":{"rendered":"Nathalie Labrecque"},"content":{"rendered":"<div  class=\" fiche-chercheur  \">\n<div class=\"img noLightbox\"><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/microbiologie.umontreal.ca\/wp-content\/uploads\/sites\/12\/2021\/08\/N_Labrecque_2021-450x359.png\" alt=\"\" width=\"450\" height=\"359\" class=\"alignnone size-medium wp-image-12094\" srcset=\"https:\/\/microbiologie.umontreal.ca\/wp-content\/uploads\/sites\/12\/2021\/08\/N_Labrecque_2021-450x359.png 450w, https:\/\/microbiologie.umontreal.ca\/wp-content\/uploads\/sites\/12\/2021\/08\/N_Labrecque_2021.png 456w\" sizes=\"auto, (max-width: 450px) 100vw, 450px\" \/><\/p>\n<p><\/div>\n<table style=\"width: 317px\">\n<tbody>\n<tr>\n<td style=\"width: 66px\"><strong>Title:<\/strong><\/td>\n<td style=\"width: 237px\">Full time professor<br \/>\nD\u00e9partement de m\u00e9decine et sp\u00e9cialit\u00e9s m\u00e9dicales<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 66px\"><strong>Address:<\/strong><\/td>\n<td style=\"width: 237px\">Maisonneuve-Rosemont Hospital<br \/>\nResearch Center<br \/>\nPolyclinique #305<br \/>\n5415 l\u2019Assomption Blvd<br \/>\nMontreal (Quebec) H1T 2M4<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 66px\"><strong>Phone:<\/strong><\/td>\n<td style=\"width: 237px\">Office: 514 252-3552<br \/>\nLab\u00a0: 514-252-3400 #4643<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 66px\"><strong>Fax:<\/strong><\/td>\n<td style=\"width: 237px\">514 253-7626<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 66px\"><strong>Email:<\/strong><\/td>\n<td style=\"width: 237px\"><a href=\"mailto:nathalie.labrecque@umontreal.ca\">nathalie.labrecque@umontreal.ca<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div><br \/>\n<hr\/><\/p>\n<h2 style=\"text-align: justify\"><strong>Biography<\/strong><\/h2>\n<p style=\"text-align: justify\"><strong style=\"text-align: justify\">Education:<\/strong><\/p>\n<table style=\"width: 540px\">\n<tbody>\n<tr style=\"height: 28px\">\n<td style=\"width: 98px;height: 28px\">1994-2000<\/td>\n<td style=\"width: 478px;height: 28px\">Post-doctoral fellow (Christophe Benoist and Diane Mathis), IGBMC, France<\/td>\n<\/tr>\n<tr style=\"height: 28.8125px\">\n<td style=\"width: 98px;height: 28.8125px\">1988-1994<\/td>\n<td style=\"width: 478px;height: 28.8125px\">Ph D. (Rafick-Pierre S\u00e9kaly), IRCM, Universit\u00e9 de Montr\u00e9al, Canada<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"text-align: justify\"><strong style=\"text-align: justify\">Distinctions and achievements:<\/strong><\/p>\n<table style=\"width: 538px\">\n<tbody>\n<tr>\n<td style=\"width: 100px\">2021<\/td>\n<td style=\"width: 476px\">Investigator Award, Canadian Society for Immunology<\/td>\n<\/tr>\n<tr style=\"height: 1.8125px\">\n<td style=\"width: 100px;height: 1.8125px\">2014-2015<\/td>\n<td style=\"width: 476px;height: 1.8125px\">Ph. D. Professor of the year, faculty of medicine \u2013 Universit\u00e9 de Montr\u00e9al<\/td>\n<\/tr>\n<tr style=\"height: 10px\">\n<td style=\"width: 100px;height: 10px\">2008-2011<\/td>\n<td style=\"width: 476px;height: 10px\">Senior Investigator Grant, FRQS<\/td>\n<\/tr>\n<tr style=\"height: 1px\">\n<td style=\"width: 100px;height: 1px\">2002-2007<\/td>\n<td style=\"width: 476px;height: 1px\">New Investigator Award, CIHR<\/td>\n<\/tr>\n<tr style=\"height: 22px\">\n<td style=\"width: 100px;height: 22px\">1997-1999<\/td>\n<td style=\"width: 476px;height: 22px\">Centennial Award, Medical Research Council of Canada<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"text-align: justify\"><hr\/><\/p>\n<h2 style=\"text-align: justify\"><strong>Team<\/strong><\/h2>\n<ul style=\"text-align: justify\">\n<li>Laure Le Corre, Ph. D. student<\/li>\n<li>Sarh Mezrag, M. Sc. student<\/li>\n<li>Salix Boulet Ph. D., Research associate<\/li>\n<li>Jean-Fran\u00e7ois Daudelin M. Sc., Lab manager<\/li>\n<li>Dave Maurice-De Sousa, Ph. D. student<\/li>\n<li>Livia Odagiu, Ph. D. student<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><hr\/><\/p>\n<h2 style=\"text-align: justify\"><strong>Theme<\/strong><\/h2>\n<p style=\"text-align: justify\">Molecular Immunology<\/p>\n<p style=\"text-align: justify\"><hr\/><\/p>\n<h2 style=\"text-align: justify\"><strong>Research topics<\/strong><\/h2>\n<p style=\"text-align: justify\">The main goal of our research group is to determine the factors involved in the differentiation of effector and memory CD8<sup>+ <\/sup>T cells. More specifically, we are interested in the Notch signaling pathway and the orphan receptor NR4A3 in acute (<em>Listeria monocytogenes<\/em> and LCMV Armstrong) and chronic (LCMV clone 13) infectious mouse models. In addition, we are currently exploring the advantages of using resident memory T cells in adoptive cell transfer to treat cancer. In parallel, we are deciphering the role of NR4A3 in different dendritic cell sub-populations. In order to attain our objectives, we use cutting edge technology, such as flow cytometry, RNA-sequencing, <em>In vivo <\/em>Imaging System (IVIS), quantitative PCR and chromatin immunoprecipitation (ChIP).<\/p>\n<hr\/>\n<h2 style=\"text-align: justify\"><strong>Publications<\/strong><\/h2>\n<p>Boulet S, Odagiu L, Dong M, Lebel M\u00c8, Daudelin JF, Melichar HJ,\u00a0<strong>Labrecque N.\u00a0<\/strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34312259\/\">NR4A3 Mediates Thymic Negative Selection.<\/a>\u00a0J Immunol. 2021 Jul 26:ji1901228. doi: 10.4049\/jimmunol.1901228. Online ahead of print.PMID:\u00a034312259<\/p>\n<p>Odagiu L, Boulet S, Maurice De Sousa D, Daudelin JF, Nicolas S,\u00a0<strong>Labrecque N.\u00a0<\/strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32913051\/\">Early programming of CD8<sup>+<\/sup>\u00a0T cell response by the orphan nuclear receptor NR4A3.<\/a>\u00a0Proc Natl Acad Sci U S A. 2020 Sep 29;117(39):24392-24402.<\/p>\n<p>Nobis CC, Dubeau Laram\u00e9e G, Kervezee L, Maurice De Sousa D,\u00a0<strong>Labrecque N*<\/strong>, Cermakian N*.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31527231\/\">The circadian clock of CD8 T cells modulates their early response to vaccination and the rhythmicity of related signaling pathways.\u00a0<\/a>Proc Natl Acad Sci U S A. 2019 Oct 1;116(40):20077-20086.<\/p>\n<p>Boulet S, Daudelin JF, Odagiu L, Pelletier AN, Yun TJ, Lesage S, Cheong C,\u00a0<strong>Labrecque N.\u00a0<\/strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31285338\/\">The orphan nuclear receptor NR4A3 controls the differentiation of monocyte-derived dendritic cells following microbial stimulation.\u00a0<\/a>Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):15150-15159.<\/p>\n<p>Mathieu M, Duval F, Daudelin JF,\u00a0<strong>Labrecque N.\u00a0<\/strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25972473\/\">The Notch signaling pathway controls short-lived effector CD8+ T cell differentiation but is dispensable for memory generation.<\/a>\u00a0J Immunol. 2015 Jun 15;194(12):5654-62.<\/p>\n<p style=\"text-align: justify\">Complete list of Dr Labrecque\u2019s publications:<\/p>\n<p style=\"text-align: justify\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=nathalie+labrecque\"><strong>https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=nathalie+labrecque<\/strong><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Biography Education: 1994-2000 Post-doctoral fellow (Christophe Benoist and Diane Mathis), IGBMC, France 1988-1994 Ph D. (Rafick-Pierre S\u00e9kaly), IRCM, Universit\u00e9 de Montr\u00e9al, Canada Distinctions and achievements: 2021 Investigator Award, Canadian Society [&hellip;]<\/p>\n","protected":false},"author":25,"featured_media":0,"parent":11407,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-7825","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Nathalie Labrecque - D\u00e9partement de microbiologie, infectiologie et immunologie - Universit\u00e9 de Montr\u00e9al<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/microbiologie.umontreal.ca\/en\/professeurs-chercheurs\/nathalie-labrecque-ph-d\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nathalie Labrecque - D\u00e9partement de microbiologie, infectiologie et immunologie - Universit\u00e9 de Montr\u00e9al\" \/>\n<meta property=\"og:description\" content=\"Biography Education: 1994-2000 Post-doctoral fellow (Christophe Benoist and Diane Mathis), IGBMC, France 1988-1994 Ph D. 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