{"id":7871,"date":"2017-06-15T19:56:41","date_gmt":"2017-06-15T18:56:41","guid":{"rendered":"https:\/\/microbiologie.umontreal.ca\/fabien-touzot\/"},"modified":"2020-10-08T16:57:25","modified_gmt":"2020-10-08T15:57:25","slug":"fabien-touzot","status":"publish","type":"page","link":"https:\/\/microbiologie.umontreal.ca\/en\/professeurs-chercheurs\/fabien-touzot\/","title":{"rendered":"Fabien Touzot"},"content":{"rendered":"<div  class=\" fiche-chercheur  \">\n<div class=\"img noLightbox\"><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/microbiologie.umontreal.ca\/wp-content\/uploads\/sites\/12\/2017\/06\/Touzot-photo.jpg\" alt=\"\" width=\"256\" height=\"327\" class=\"alignnone size-full wp-image-6739\" \/><\/p>\n<p><\/div>\n\n<table style=\"width: 386px\">\n<tbody>\n<tr>\n<td style=\"width: 70px\"><strong>Title:<\/strong><\/td>\n<td style=\"width: 302px\">Clinical associate professor (accredited)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 70px\"><strong>Address:<\/strong><\/td>\n<td style=\"width: 302px\">D\u00e9partement de p\u00e9diatrie<br \/>\nCentre de recherche du CHU Sainte-Justine<br \/>\n3175, ch. C\u00f4te Ste-Catherine<br \/>\nMontr\u00e9al (Qu\u00e9bec) H3T 1C5<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 70px\"><strong>Room:<\/strong><\/td>\n<td style=\"width: 302px\">Office: 6.17.15<br \/>\nLab: 6.17.315_10<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 70px\"><strong>Phone:<\/strong><\/td>\n<td style=\"width: 302px\">Office: 514-345-4931, ext. 7603<br \/>\nLab: 514-345-4931, ext. 7609<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 70px\"><strong>Email:<\/strong><\/td>\n<td style=\"width: 302px\"><a href=\"mailto:fabien.touzot@umontreal.ca\">fabien.touzot@umontreal.ca<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div><br \/>\n<hr\/><\/p>\n<h2 style=\"text-align: justify\"><strong>Biography<\/strong><\/h2>\n<p style=\"text-align: justify\">After training as a clinician-researcher in pediatric immunology and hematology, Fabien Touzot was the doctor in charge of the cell and gene therapy laboratory of the Necker Enfants Malades hospital from 2012 to 2016. Dr. Touzot joined the hospital&#8217;s research center Sainte-Justine in October 2016 to develop a gene therapy program for hematopoietic cells for immuno-hematological pathologies. His lab works also on deciphering the pathophysiological mechanism of inflammasome dysregulation in auto-inflammatory diseases.<\/p>\n<hr\/>\n<h2 style=\"text-align: justify\"><strong>Team<\/strong><\/h2>\n<ul style=\"text-align: justify\">\n<li>Aissa Benyoucef, research assistant<\/li>\n<li>Lorie Marchitto, master student<\/li>\n<\/ul>\n<hr\/>\n<h2 style=\"text-align: justify\"><strong>Theme<\/strong><\/h2>\n<ul style=\"text-align: justify\">\n<li>Immunology<\/li>\n<li>Repair of DNA<\/li>\n<\/ul>\n<hr\/>\n<h2 style=\"text-align: justify\"><strong>Research topics<\/strong><\/h2>\n<ul style=\"text-align: justify\">\n<li>Gene therapy of hematopoietic cells by gene editing.<\/li>\n<li>Pathophysiological mechanisms of inflammatory manifestations during auto-inflammatory disease.<\/li>\n<\/ul>\n<hr\/>\n<h2 style=\"text-align: justify\"><strong>Publications<\/strong><\/h2>\n<ul>\n<li style=\"text-align: justify\">Mammalian target of rapamycin inhibition counterbalances the inflammatory status of immune cells in patients with chronic granulomatous disease. Gabrion A, Hmitou I, Moshous D, Neven B, Lef\u00e8vre-Utile A, Diana JS, Suarez F, Picard C, Blanche S, Fischer A, Cavazzana M, <strong>Touzot F<\/strong>. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27702670\"><strong>J Allergy Clin Immunol.<\/strong> 2017 May;139(5):1641-1649.<\/a><\/li>\n<li style=\"text-align: justify\">An in vivo genetic reversion highlights the crucial role of Myb-Like, SWIRM, and MPN domains 1 (MYSM1) in human hematopoiesis and lymphocyte differentiation. Le Guen T, <strong>Touzot F<\/strong>, Andr\u00e9-Schmutz I, Lagresle-Peyrou C, France B, Kermasson L, Lambert N, Picard C, Nitschke P, Carpentier W, Bole-Feysot C, Lim A, Cavazzana M, Callebaut I, Soulier J, Jabado N, Fischer A, de Villartay JP, Revy P. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26220525\"><strong>J Allergy Clin Immunol.<\/strong> 2015 Dec;136(6):1619-26.<\/a><\/li>\n<li style=\"text-align: justify\">Unraveling the pathogenesis of Hoyeraal-Hreidarsson syndrome, a complex telomere biology disorder. Glousker G, <strong>Touzot F<\/strong>, Revy P, Tzfati Y, Savage SA. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25940403\"><strong>Br<\/strong> <strong>J Haematol.<\/strong> 2015 Aug;170(4):457-71<\/a>.<\/li>\n<li style=\"text-align: justify\">Faster T-cell development following gene therapy compared with haploidentical HSCT in the treatment of SCID-X1. <strong>Touzot F<\/strong>, Moshous D, Creidy R, Neven B, Frange P, Cros G, Caccavelli L, Blondeau J, Magnani A, Luby JM, Ternaux B, Picard C, Blanche S, Fischer A, Hacein-Bey-Abina S, Cavazzana M. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25869287\"><strong>Blood.<\/strong> 2015 Jun 4;125(23):3563-9.<\/a><\/li>\n<li style=\"text-align: justify\">Gene therapy for inherited immunodeficiency. <strong>Touzot F<\/strong>, Hacein-Bey-Abina S, Fischer A, Cavazzana M. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24823313\"><strong>Expert Opin Biol Ther<\/strong> 2014 Jun;14(6):789-98<\/a>.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Biography After training as a clinician-researcher in pediatric immunology and hematology, Fabien Touzot was the doctor in charge of the cell and gene therapy laboratory of the Necker Enfants Malades [&hellip;]<\/p>\n","protected":false},"author":26,"featured_media":0,"parent":11407,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-7871","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.0 - 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