{"id":8188,"date":"2014-07-30T15:18:57","date_gmt":"2014-07-30T15:18:57","guid":{"rendered":"https:\/\/microbiologie.umontreal.ca\/helene-decaluwe\/"},"modified":"2021-08-25T18:49:41","modified_gmt":"2021-08-25T17:49:41","slug":"helene-decaluwe","status":"publish","type":"page","link":"https:\/\/microbiologie.umontreal.ca\/en\/professeurs-chercheurs\/helene-decaluwe\/","title":{"rendered":"H\u00e9l\u00e8ne Decaluwe"},"content":{"rendered":"<div  class=\" fiche-chercheur  \">\n<div class=\"img noLightbox\"><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/microbiologie.umontreal.ca\/wp-content\/uploads\/sites\/12\/2018\/06\/Decaluwe-H\u00e9l\u00e8ne-300x450.jpg\" alt=\"\" width=\"300\" height=\"450\" class=\"alignnone size-medium wp-image-8173\" srcset=\"https:\/\/microbiologie.umontreal.ca\/wp-content\/uploads\/sites\/12\/2018\/06\/Decaluwe-H\u00e9l\u00e8ne-300x450.jpg 300w, https:\/\/microbiologie.umontreal.ca\/wp-content\/uploads\/sites\/12\/2018\/06\/Decaluwe-H\u00e9l\u00e8ne-683x1024.jpg 683w, https:\/\/microbiologie.umontreal.ca\/wp-content\/uploads\/sites\/12\/2018\/06\/Decaluwe-H\u00e9l\u00e8ne-610x915.jpg 610w, https:\/\/microbiologie.umontreal.ca\/wp-content\/uploads\/sites\/12\/2018\/06\/Decaluwe-H\u00e9l\u00e8ne.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p><\/div>\n<table class=\"fiche-chercheur\" style=\"width: 358px\">\n<tbody>\n<tr>\n<td style=\"width: 99px\"><strong>Title:<\/strong><\/td>\n<td style=\"width: 312px\">Clinical associate professor (accredited)<br \/>\nD\u00e9partement de p\u00e9diatrie<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 99px\"><strong>Address:<\/strong><\/td>\n<td style=\"width: 312px\">Centre de recherche du CHU Ste-Justine<br \/>\n3175, ch. C\u00f4te-Ste-Catherine<br \/>\nMontr\u00e9al (Qu\u00e9bec)<br \/>\nH3T 1C5<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 99px\"><strong>Phone:<\/strong><\/td>\n<td style=\"width: 312px\">514-345-4931, ext. 4713<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 99px\"><strong>Fax:<\/strong><\/td>\n<td style=\"width: 312px\">514-345-4897<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 99px\"><strong>Email:<\/strong><\/td>\n<td style=\"width: 312px\"><a href=\"mailto:helene.decaluwe@umontreal.ca\">helene.decaluwe@umontreal.ca<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<hr\/>\n<h2 style=\"text-align: justify\"><strong>Biography<\/strong><\/h2>\n<p style=\"text-align: justify\">Update coming soon<\/p>\n<p style=\"text-align: justify\"><hr\/><\/p>\n<h2 style=\"text-align: justify\"><strong>Team <\/strong><\/h2>\n<ul style=\"text-align: justify\">\n<li>Beno\u00eete Bourdin, associ\u00e9e de recherche<\/li>\n<li>Jos\u00e9e-Anne Joly, assistante de recherche<\/li>\n<li>Mitra Shourian, Post-doc<\/li>\n<li>Alexis Vall\u00e9e, Ph.D.<\/li>\n<li>Cl\u00e9mence Ruisseaux, Ph.D.<\/li>\n<li>Sabryna Nantel, Ph.D.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><hr\/><\/p>\n<h2 style=\"text-align: justify\"><strong>Theme<\/strong><\/h2>\n<ul style=\"text-align: justify\">\n<li>Immunology<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><hr\/><\/p>\n<h2 style=\"text-align: justify\"><strong>Research topics<\/strong><\/h2>\n<p style=\"text-align: justify\">As a Clinician Scientist in Pediatric Immunology, the primary focus of my research is to better understand the role of cytokines in the differentiation of CD8 T cells in health and disease, and to develop novel immunotherapeutic approaches that target cytokine-dependent pathways and inhibitory receptors expressed on CD8 T cells, to cure chronic viral infections and cancer. Supported by both national (Canadian Institutes of Health Research, National Institute of Health) and private (Leukemia and Lymphoma Society of Canada, Canadian Cancer Society\/Cole Foundation, Charles Bruneau Foundation) funding agencies, my laboratory has established a solid expertise in the field of T cell exhaustion, a differentiation pathway that precludes memory T cell development and limits optimal T effector cell functions. We are particularly involved in identifying the cytokine-dependent signaling pathways and transcription factors regulating T cell exhaustion during disease. We further aim to develop novel combined immunotherapeutic approaches that target inhibitory receptors and signaling pathways, to improve cure rates in cancer refractory patients. Finally, we developed a particular expertise in the immune reconstitution of severe combined immunodeficiency patients treated by stem cell transplantation, with the goal to inform on the best therapeutic approaches to transplant these patients.<\/p>\n<p style=\"text-align: justify\"><hr\/><\/p>\n<h2 style=\"text-align: justify\"><strong>Publications<\/strong><\/h2>\n<p>Marois L, Touzot F, Haddad E, Fernandez I, Morin MP, De Bruycker JJ, Duval M, Cellot S, Teira P, Bittencourt H,\u00a0<strong>Decaluwe H<\/strong>. Successful management of familial hemophagocytic lymphohistiocytosis by the JAK 1\/2 inhibitor ruxolitinib.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33694335\/\"><strong>Pediatr Blood Cancer<\/strong>. 2021 Jun;68(6):e28954. doi: 10.1002\/pbc.28954. Epub 2021 Mar 10. PMID: 33694335.<\/a><\/p>\n<p>Shourian M, Beltra JC, Bourdin B,\u00a0<strong>Decaluwe H<\/strong>. Common gamma chain cytokines and CD8 T cells in cancer.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31604532\/\"><strong>Semin Immunol<\/strong>. 2019 Apr;42:101307. doi: 10.1016\/j.smim.2019.101307. PMID: 31604532.<\/a><\/p>\n<p>Palacio L, Goyer ML, Maggiorani D, Espinosa A, Villeneuve N, Bourbonnais S, Moquin-Beaudry G, Le O, Demaria M, Davalos AR,\u00a0<strong>Decaluwe H<\/strong>, Beaus\u00e9jour C. Restored immune cell functions upon clearance of senescence in the irradiated splenic environment.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31148373\/\"><strong>Aging Cell<\/strong>. 2019 Aug;18(4):e12971. doi: 10.1111\/acel.12971. Epub 2019 May 31. PMID: 31148373; PMCID: PMC6612633.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Biography Update coming soon Team Beno\u00eete Bourdin, associ\u00e9e de recherche Jos\u00e9e-Anne Joly, assistante de recherche Mitra Shourian, Post-doc Alexis Vall\u00e9e, Ph.D. Cl\u00e9mence Ruisseaux, Ph.D. Sabryna Nantel, Ph.D. Theme Immunology Research [&hellip;]<\/p>\n","protected":false},"author":25,"featured_media":0,"parent":11407,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-8188","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>H\u00e9l\u00e8ne Decaluwe - D\u00e9partement de microbiologie, infectiologie et immunologie - Universit\u00e9 de Montr\u00e9al<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/microbiologie.umontreal.ca\/en\/professeurs-chercheurs\/helene-decaluwe\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"H\u00e9l\u00e8ne Decaluwe - 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