|Title:||Clinical associate professor (accredited)
Département de pédiatrie
|Address:||Centre de recherche du CHU Ste-Justine
3175, ch. Côte-Ste-Catherine
|Phone:||514-345-4931, ext. 4713|
Update coming soon
- Benoîte Bourdin, associée de recherche
- Josée-Anne Joly, assistante de recherche
- Mitra Shourian, Post-doc
- Alexis Vallée, Ph.D.
- Clémence Ruisseaux, Ph.D.
- Sabryna Nantel, Ph.D.
As a Clinician Scientist in Pediatric Immunology, the primary focus of my research is to better understand the role of cytokines in the differentiation of CD8 T cells in health and disease, and to develop novel immunotherapeutic approaches that target cytokine-dependent pathways and inhibitory receptors expressed on CD8 T cells, to cure chronic viral infections and cancer. Supported by both national (Canadian Institutes of Health Research, National Institute of Health) and private (Leukemia and Lymphoma Society of Canada, Canadian Cancer Society/Cole Foundation, Charles Bruneau Foundation) funding agencies, my laboratory has established a solid expertise in the field of T cell exhaustion, a differentiation pathway that precludes memory T cell development and limits optimal T effector cell functions. We are particularly involved in identifying the cytokine-dependent signaling pathways and transcription factors regulating T cell exhaustion during disease. We further aim to develop novel combined immunotherapeutic approaches that target inhibitory receptors and signaling pathways, to improve cure rates in cancer refractory patients. Finally, we developed a particular expertise in the immune reconstitution of severe combined immunodeficiency patients treated by stem cell transplantation, with the goal to inform on the best therapeutic approaches to transplant these patients.
Marois L, Touzot F, Haddad E, Fernandez I, Morin MP, De Bruycker JJ, Duval M, Cellot S, Teira P, Bittencourt H, Decaluwe H. Successful management of familial hemophagocytic lymphohistiocytosis by the JAK 1/2 inhibitor ruxolitinib. Pediatr Blood Cancer. 2021 Jun;68(6):e28954. doi: 10.1002/pbc.28954. Epub 2021 Mar 10. PMID: 33694335.
Shourian M, Beltra JC, Bourdin B, Decaluwe H. Common gamma chain cytokines and CD8 T cells in cancer. Semin Immunol. 2019 Apr;42:101307. doi: 10.1016/j.smim.2019.101307. PMID: 31604532.
Palacio L, Goyer ML, Maggiorani D, Espinosa A, Villeneuve N, Bourbonnais S, Moquin-Beaudry G, Le O, Demaria M, Davalos AR, Decaluwe H, Beauséjour C. Restored immune cell functions upon clearance of senescence in the irradiated splenic environment. Aging Cell. 2019 Aug;18(4):e12971. doi: 10.1111/acel.12971. Epub 2019 May 31. PMID: 31148373; PMCID: PMC6612633.