Marylise Duperthuy

Title: Full time assistant professor
Address: Département de microbiologie, infectiologie et immunologie
Université de Montréal
C.P. 6128, Succ. Centre-ville
Montréal (Québec)
H3C 3J7
Room: Office: S-621, Pavillon Roger-Gaudry
Labo: U-621, Pavillon Roger-Gaudry
Phone: Office: 514-343-6111, ext. 32942
Labo: To come up
Fax: 514-343-5701


After a Master of Science and Technology in biochemistry at the University of La Rochelle (France), Marylise Duperthuy completed her doctoral studies in microbiology at the University of Montpellier 2 under the supervision of Dr. Delphine Destoumieux-Garzòn (2007- 2010). She investigated the role of the OmpU porin of Vibrio splendidus in the interaction with its host, the oyster Crassostrea gigas. She investigated the resistance of the Vibrio to the oyster’s antimicrobial peptides, its virulence, and its pathogenesis. Her doctoral study was nominated for the trophy of the best thesis of the French Institute for Research and Exploitation of the Sea (Ifremer) in 2011. Dr. Duperthuy completed a postdoctoral fellowship, followed by a research associate position in Prof. Sun Nyunt Wai’s group at the University of Umea (Sweden) in the Molecular Infection Medicine Sweden (MIMS) Center (2011-2016). She was working on the role of bacterial outer membrane vesicles in resistance of Vibrio to antimicrobial peptides. She joined the Department of Microbiology, Infectiology and Immunology at the Université de Montréal in 2016. Her research program aims to understand the bacterial interactions by focusing on the modulation of virulence by molecules produced by the microbiota, including antimicrobial peptides, as well as studying the mechanisms of antimicrobial resistance in Vibrio cholerae.


  • Sean Giacomucci (étudiant au PhD.)
  • Annabelle Mathieu-Denoncourt (étudiante au PhD.)
  • Hanen Jannadi (étudiante au PhD.)
  • Clément Baret (étudiant à la M.Sc.)
  • Julien Pauzé-Foixet (étudiant à la M.Sc.)


  • Bacteriology

Research topics

Update coming soon


Myint SL, Zlatkov N, Aung KM, Toh E, Sjöström A, Nadeem A, Duperthuy M, Uhlin BE, Wai SN. Ecotin and LamB in Escherichia coli influence the susceptibility to Type VI secretion-mediated interbacterial competition and killing by Vibrio cholerae. Biochim Biophys Acta Gen Subj. 2021 Jul;1865(7):129912. doi: 10.1016/j.bbagen.2021.129912. Epub 2021 Apr 20. PMID: 33892013.

Annabelle Mathieu-Denoncourt, Sean Giacomucci and Marylise Duperthuy (March 19th 2021). The Secretome of <em>Vibrio cholerae</em> [Online First], IntechOpen, DOI: 10.5772/intechopen.96803. Available from:

Giacomucci S, Cros CD, Perron X, Mathieu-Denoncourt A, Duperthuy M. Flagella-dependent inhibition of biofilm formation by sub-inhibitory concentration of polymyxin B in Vibrio cholerae. PLoS One. 2019 Aug 20;14(8):e0221431. doi: 10.1371/journal.pone.0221431. PMID: 31430343; PMCID: PMC6701800.

Duperthuy M. Antimicrobial Peptides: Virulence and Resistance Modulation in Gram-Negative Bacteria. Microorganisms. 2020 Feb 19;8(2):280. doi: 10.3390/microorganisms8020280. PMID: 32092866; PMCID: PMC7074834.