Centre de recherche
5415, boul. l’Assomption
Montréal (Québec) H1T 2M4
|Room:||Room 305, polyclinique|
|Phone:||Office: 514-252-3400, ext. 4649
Lab: 514-252-3400, ext. 4653
Dr. Sylvie Lesage received her BSc from the Interdepartmental Immunology Program at McGill University. Subsequently, she completed her Ph.D. in Experimental Medicine under the supervision of Dr. Patrice Hugo, where she studied the mechanisms of central T cell tolerance. She then undertook a postdoctoral internship under the supervision of Dr. Christopher C. Goodnow, recognized internationally for is work in immunogenetics. During this internship in Australia, Dr. Lesage took advantage of murine models to study the genetic predisposition to autoimmune diseases, such as type 1 diabetes. While it was established that peripheral tolerance of lymphocytes T contributed significantly to the predisposition to autoimmune diseases, Dr. Lesage’s work revealed an important contribution of central tolerance. Dr. Lesage opened her laboratory in the fall of 2005 at Maisonneuve-Rosemont Hospital where she established a research team to define the biology and genetics of the immune system’s cellular populations that contribute to immune tolerance and thus preventing autoimmune diseases.
- Lise Coderre, associée de recherche
- Geneviève Chabot-Roy, assistante de recherche
- Ernesto Fajardo Despaigne, assistant de recherche
- Sarah Pasquin, stagiaire post-doctorale
- Antoine Leblanc-Hotte, stagiaire post-doctoral
- Félix Lombard-Vadnais, étudiant au doctorat
- Adrien Fois, étudiant au doctorat
- Anne-Marie Aubin, étudiante à la maîtrise
- Aïnhoa Olazabal, étudiante à la maîtrise
- Capucine Bourel, étudiante à la maîtrise
- Joëlle Plourde, étudiante à la maîtrise
- Our research projects aim to measure the importance of homeostasis of different immune cell populations in order to identify the impact of each cell on the predisposition to complex genetic diseases such as autoimmune diseases and cancer. Various basic research projects are underway on a variety of subjects, including NK cells, dendritic cells and T lymphocytes. We also conduct applied research on inflammation, type 1 diabetes and graft-vs-host disease, among others.
- Dong M, Audiger C, Adegoke A, Lebel MÈ, Valbon SF, Anderson CC, Melichar HJ, Lesage S. CD5 levels reveal distinct basal T-cell receptor signals in T cells from non-obese diabetic mice. Immunol Cell Biol. 2021 Jul;99(6):656-667. doi: 10.1111/imcb.12443. Epub 2021 Mar 8. PubMed PMID: 33534942.
- Fois A, Boucher-Lafleur AM, Thompson Legault J, Renaud C, Morin C, Des Rosiers C, Coderre L, Laprise C, Lesage S. Humoral responses to the measles, mumps and rubella vaccine are impaired in Leigh Syndrome French Canadian patients. PLoS One. 2020;15(10):e0239860. doi: 10.1371/journal.pone.0239860. eCollection 2020. PubMed PMID: 33085679; PubMed Central PMCID: PMC7577467.
- Collin R, Lombard-Vadnais F, Hillhouse EE, Lebel MÈ, Chabot-Roy G, Melichar HJ, Lesage S. MHC-Independent Thymic Selection of CD4 and CD8 Coreceptor Negative αβ T Cells. J Immunol. 2020 Jul 1;205(1):133-142. doi: 10.4049/jimmunol.2000156. Epub 2020 May 20. PubMed PMID: 32434937.