Centre de recherche
5415, boul. l’Assomption
Montréal (Québec) H1T 2M4
|Room:||Room 305, polyclinique|
|Phone:||Office: 514-252-3400, ext. 4649
Lab: 514-252-3400, ext. 4653
Dr. Sylvie Lesage received her BSc from the Interdepartmental Immunology Program at McGill University. Subsequently, she completed her Ph.D. in Experimental Medicine under the supervision of Dr. Patrice Hugo, where she studied the mechanisms of central T cell tolerance. She then undertook a postdoctoral internship under the supervision of Dr. Christopher C. Goodnow, recognized internationally for is work in immunogenetics. During this internship in Australia, Dr. Lesage took advantage of murine models to study the genetic predisposition to autoimmune diseases, such as type 1 diabetes. While it was established that peripheral tolerance of lymphocytes T contributed significantly to the predisposition to autoimmune diseases, Dr. Lesage’s work revealed an important contribution of central tolerance. Dr. Lesage opened her laboratory in the fall of 2005 at Maisonneuve-Rosemont Hospital where she established a research team to define the biology and genetics of the immune system’s cellular populations that contribute to immune tolerance and thus preventing autoimmune diseases.
- Geneviève Chabot-Roy, research assistant
- Erin Hillhouse, research associate
- Victor Mullins-Dansereau, MSc student
- Félix Lombard-Vadnais, MSc student
- Cindy Audiger, PhD student
- Our research projects aim to measure the importance of homeostasis of different immune cell populations in order to identify the impact of each cell on the predisposition to complex genetic diseases such as autoimmune diseases and cancer. Various basic research projects are underway on a variety of subjects, including NK cells, dendritic cells and T lymphocytes. We also conduct applied research on inflammation, type 1 diabetes and graft-vs-host disease, among others.
- Collin R, St-Pierre C, Guilbault L, Mullins-Dansereau V, Policheni A, Guimont-Desrochers F, Pelletier AN, Gray DH, Drobetsky, E, Perreault C, Hillhouse EE, Lesage S. An unbiased linkage approach reveals that the p53 pathway is intimately coupled to NK cell functional maturation. 2017. J Immunol. 199 (4) :1490-1504. doi: 10.4049/jimmunol.1600789
- Audiger, C., Rahman, M.J., Yun, T.J., Tarbell, K., Lesage, S. The importance of dendritic cells in maintaining immune tolerance. 2017. J Immunol. 198 (6) 2223-2231; doi: 10.4049/jimmunol.1601629.
- Collin, R., Dugas, V., Chabot-Roy, G., Salem, D., Zahn, A., Di Noia, J.M., Rauch, J., Lesage, S.. Autoimmunity and antibody affinity maturation are modulated by genetic variants on mouse chromosome 12. 2015. J. Autoimmun. 58 : 90-99. doi: 10.1016/j.jaut.2015.01.007.