Marie Sarfati

Biographie

MD PhD

Directeur du laboratoire d’Immunorégulation ( CRCHUM).

Professeur titulaire, Département de Médecine, Université de Montréal

Personnel de laboratoire

• Marwa Bsat, étudiante Ph.D.
• Laurence Anne Chapuy, étudiante Ph.D.
• Heena Mehta, Associée de recherche
• AmélieTherrien, étudiante MSc.
• Shunya Mashiko, assistant de recherche
• Manuel Rubio, assistant de recherche

Thèmes

Maladies inflammatoires chroniques de la peau (psoriasis, dermatite atopique, sclérodermie)

Maladies inflammatoires chroniques de l’intestin (maladie de Crohn, colite ulcéresue)

Maladies allergiques

Sujets de recherche

• Caractérisation et fonction des cellules innées et des lymphocytes T dans les tissus de malades atteints de maladie inflammatoire chronique.

Publications choisies

Early-Life Antibiotic Exposure Causes Intestinal Dysbiosis and Exacerbates Skin and Lung Pathology in Experimental Systemic Sclerosis.Mehta H, Goulet PO, Mashiko S, Desjardins J, Pérez G, Koenig M, Senécal JL, Constante M, Santos MM, Sarfati M.J Invest Dermatol. 2017 Nov;137(11):2316-2325. doi: 10.1016/j.jid.2017.06.019. Epub 2017 Jul 27.

Increased frequencies of basophils, type 2 innate lymphoid cells and Th2 cells in skin of patients with atopic dermatitis but not psoriasis.Mashiko S, Mehta H, Bissonnette R, Sarfati M.J Dermatol Sci. 2017 Nov;88(2):167-174. doi: 10.1016/j.jdermsci.2017.07.003. Epub 2017 Jul 15.

Persistence of interleukin (IL)-17A+ T lymphocytes and IL-17A expression in treatment-resistant psoriatic plaques despite ustekinumab therapy.Jack C, Mashiko S, Arbour N, Bissonnette R, Sarfati M.Br J Dermatol. 2017 Jul;177(1):267-270. doi: 10.1111/bjd.15029. Epub 2017 Jun 6.

Differential accumulation and function of proinflammatory 6-sulfo LacNAc dendritic cells in lymph node and colon of Crohn’s versus ulcerative colitis patients.Bsat M, Chapuy L, Baba N, Rubio M, Panzini B, Wassef R, Richard C, Soucy G, Mehta H, Sarfati M.J Leukoc Biol. 2015 Oct;98(4):671-81. doi: 10.1189/jlb.5A1014-509RR. Epub 2015 Jul 10.

Mutual Interaction of Basophils and T Cells in Chronic Inflammatory Diseases.Sarfati M, Wakahara K, Chapuy L, Delespesse G. Front Immunol. 2015 Aug 3;6:399. doi: 10.3389/fimmu.2015.00399. eCollection 2015. Review.

Basophils increase in Crohn disease and ulcerative colitis and favor mesenteric lymph node memory TH17/TH1 response.Chapuy L, Bsat M, Mehta H, Rubio M, Wakahara K, Van VQ, Baba N, Cheong C, Yun TJ, Panzini B, Wassef R, Richard C, Tamaz R, Soucy G, Delespesse G, Sarfati M.J Allergy Clin Immunol. 2014 Oct;134(4):978-81.e1. doi: 10.1016/j.jaci.2014.05.025. Epub 2014 Jul 2.

CD47 fusion protein targets CD172a+ cells in Crohn’s disease and dampens the production of IL-1β and TNF.Baba N, Van VQ, Wakahara K, Rubio M, Fortin G, Panzini B, Soucy G, Wassef R, Richard C, Tamaz R, Lahaie R, Bernard EJ, Caussignac Y, Leduc R, Lougnarath R, Bergeron C, Racicot MA, Bergeron F, Panzini MA, Demetter P, Franchimont D, Schäkel K, Weckbecker G, Kolbinger F, Heusser C, Huber T, Welzenbach K, Sarfati M. J Exp Med. 2013 Jun 3;210(6):1251-63. doi: 10.1084/jem.20122037. Epub 2013 May 13.