Conférence du CRCHUM

Heure : 12h
Lieu : 5e étage, auditorium
Adresse : 900, rue Saint-Denis

Thomas J. Hope, Ph.D

Departments of Cell and Molecular Biology,
Obstetrics and Gynecology Northwestern University
Co-PI, The Sustained Long-Acting Protection Against HIV (SLAP HIV) Program
Director, Viral Pathogenesis Core, Third Coast Center for AIDS Research


Titre:  « Visualizing HIV Sexual Transmission and Prevention Utilizing NHP Models »


Résumé : 

The Hope Laboratory utilizes a series of imaging based tools to define key viral and host players of the earliest days of the transmission event in the physiologically relevant context of anatomy and physiology of live animals and human tissues. We use several approaches to allow the efficient identification of foci of SIV mucosal infection. HIV/SIV particles, mucosal tissue barriers, host target or effector cells, and infected cells can be directly visualized. We can leverage these imaging capabilities to do in vivo PK/PD studies utilizing systemic and topical PrEP approaches. Together, these approaches provide unique insights into the space and time of the earliest events of HIV transmission and prevention to inform the development of approaches to stem the AIDS pandemic that continues around the world.