ANNULÉ—-À VOTRE AGENDA: —ANNULÉ
Le mercredi 5 octobre 2022 à 11 h
SÉMINAIRE DE RECHERCHE DU CHUM AXE IMMUNOPATHOLOGIE
Mechanistic insights into sexual dimorphism in
colon cancer and wound healing: Interactions
between estrogen, K+ channels and Wnt/b-catenin
Brian Harvey, Ph. D.
Emeritus Professor of Molecular Medicine
Royal College of Surgeons in Ireland
Aperçu de l’exposé :
- Background to the physiology of sexual dimorphism in non-reproductive tissues
- General overview of sex differences in pathophysiology. Examples from secretory diarrhoea, cystic fibrosis, colon cancer, Covid-19.
- Mechanistic insights into molecular targets of estrogen underpinning sexual dimorphism in colon cancer
- Interactions between K+ channels and Wnt/b-catenin signaling pathways in wound healing
In this seminar I will provide mechanistic insights into sexual dimorphism in health and disease with a focus on molecular targets of the sex steroid hormone estrogen in colon cancer, cystic fibrosis, Covid-19 and wound healing.
A sex disparity has been observed in many diseases with women having better prognosis than men, for example, in colon cancer and Covid-19, whereas in cystic fibrosis male patients fare better than women (the so-called “CF gender gap”). Estrogen has also been reported to accelerate recovery in epithelial wound repair. In order to gain insights into the underlying molecular mechanisms of sex differences in the onset, progression and resolution of diseases, it is important to understand the physiological basis for sexual dimorphism in healthy non-reproductive tissues and organs. I will start the lecture with a general overview of sex differences (biological not gender) in the physiological function of kidney, lung and intestinal epithelia and how these differences confer a physiological advantage in the female during the reproductive years which will have repercussions in diseases such as secretory diarrhoea, colon cancer, Covid-19 and cystic fibrosis. I will show that sexual dimorphism in the physiological function of these tissues is mediated (but not limited) by estrogen actions on ion channels and transporters via specific protein kinase signalling pathways. This general introduction will lay the ground for an in-depth discussion of molecular mechanisms underpinning sexual dimorphism in colon cancer, CF and Covid-19. Finally, I will discuss novel findings of the interactions between K+ channels (KCNQ1, KCNN4) and Wnt/b-catenin signaling in epithelial wound repair. I will conclude the lecture with reflections on the intriguing possibility of estrogen regulation of ion channels, PKC and Wnt signalling as a common basis for sexual dimorphism in epithelial cell function in health and disease.
Invité par Emmanuelle Brochiero
Le mercredi 5 octobre 2022 à 11 h —ANNULÉ
CENTRE DE RECHERCHE DU CHUM
900, rue Saint-Denis
5e étage, amphithéâtre R05.212B
Montréal (QC) H2X 0A9
POUR REJOINDRE LA RÉUNION – PLATE FORME ZOOM : https://umontreal.zoom.us/j/85196321751?pwd=TVA4Rmg2bTVlR1NqR3FkSkJLSkYydz09
ID de réunion : 851 9632 1751
Code secret : 805231