Vibhuti Dave

Biographie

Dr. Dave received master and doctoral (biochemistry) degrees from University of Mumbai. He then pursued postdoctoral training in immunology at St. Jude Children’s Research Hospital (Memphis, USA) and Fox Chase Cancer Center (Philadelphia, USA). Dr. Dave established his research lab at IRCM. In 2002, he was awarded Canada Research Chair. Presently, he is at Centre de Recherche Hôpital Maisonneuve-Rosemont (CRHMR) where he is continuing to study CD4/CD8 lineage commitment in thymus and mature T cell function using transgenic and gene deficient mouse models.

Personnel de laboratoire

• Nabil Zeidan, Ph.D. student.

Thème

• Immunologie

Sujets de recherche

• Mechanism of ThPOK-mediated CD4/CD8 lineage choice in thymus.
• Understanding T cell exhaustion.
• Chimeric antigen receptor and cancer immunotherapy.

Publications choisies

• Brodeur JF, Li S, Damlaj O, and Dave VP. Expression of of fully-assembled T cell receptor/CD3 complex on double positive thymocytes: synergistic role for the PRS and the ER retention motifs in the intra-cytoplasmic tail of CD3ε. International Immunology 2009; 21:1317-1327.
• Brodeur JF, Li S, da Silva Martins M, Larose L, Dave VP. Critical and multiple roles for the CD3epsilon intracytoplasmic tail in double negative to double positive thymocyte differentiation. J Immunol. 2009, 182(9):4844-4853.
• Pan Q, Brodeur JF, Drbal K and Dave VP. Different role for mouse and human CD3delta/epsilon heterodimer in preT cell receptor (preTCR) function: human CD3delta/epsilon heterodimer restores the defective preTCR function in CD3gamma- and CD3gammadelta-deficient mice. Mol Immunol 2006, 43:1741-1750.
• He X, He X, Dave VP, Zhang Y, Hua X, Nicolas E, Xu W, Roe BA, Kappes DJ. The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment. Nature 2005, 433(7028):826-833.